80+ Independent Studies
Technology & Science
The Prysm iO isn't a wellness gimmick. It's a clinically-validated measurement tool supported by research from Stanford, Yonsei, Jiao Tong, and more than 80 published studies.
Spectral Rai™ Measurement Technology
At the heart of the Prysm iO is the patent-pending Spectral Rai™ technology. Each scan fires more than 700,000 hyperspectral absorption measurements at the skin in just 15 seconds to detect carotenoid molecules with extraordinary precision.
A machine learning calibration engine maps those measurements against validated reference populations to deliver your personalised Prysm Score — a number that reflects your antioxidant defence in real time.
Spectral Rai™ builds on decades of foundational resonance Raman spectroscopy research, which helped establish and validate non-invasive skin-carotenoid measurement as a science.
From Measurement to Personalised Guidance
The Technology Doesn't Stop at the Score.
The dedicated PRYSM app combines the individual's score and lifestyle information with AI-powered technology supported by insights from more than 20 million historical antioxidant scans to provide personalised guidance across nutrition, lifestyle, fitness and supplementation.
Nutrition · Lifestyle · Fitness · Supplementation
Independent Research
World-Leading Institutions Back the Data
Four independent university studies have examined Prysm iO technology — each confirming its validity from a different scientific angle.
Blood Serum Carotenoid Correlation with Prysm iO
Validated Prysm iO readings against blood serum carotenoid levels, confirming scan accuracy as a non-invasive biomarker.
Diet, Lifestyle, Skin & Metabolism vs Prysm Score
Mapped how diet quality, lifestyle habits, skin health, and metabolic markers correlate with Prysm Score outcomes.
LifePak® Effect on Prysm Score & Lifestyle
Demonstrated clinically significant Prysm Score improvements in participants using Pharmanex® LifePak® supplementation.
Skin & Wellness Factor Correlation
Found consistent associations between higher Prysm scores, slower biological ageing, and healthier telomere markers across multiple ageing clocks.
Biological Ageing
Higher Prysm Score, Slower Biological Ageing
All four independent ageing clocks point the same direction (N = 33). The top Prysm tertile averages 3–5 years younger on every single clock.
| Ageing Clock | r vs Prysm | p-value | Direction |
|---|---|---|---|
| Symphony Age | −0.25 | 0.16 | Lower bio-age → higher Prysm |
| Pace of Aging | −0.24 | 0.18 | Slower pace → higher Prysm |
| Telomere Bio Age | −0.23 | 0.20 | Younger telomere age → higher Prysm |
| OMICm Age | −0.21 | 0.23 | Lower bio-age → higher Prysm |
| Telomere Length | +0.23 | 0.20 | Longer telomeres → higher Prysm |
Tertile Comparison
Top-Prysm tertile averages 3–5 years younger on every ageing clock
- Symphony Age: 51.6 vs 56.6
- OMICm Age: 49.6 vs 52.9
- Pace of Ageing: 0.94 vs 0.97
- Telomeres favour high scorers on both metrics
Collaborative study with Dr Anne Chang (pending publication)
Verdict
All four independent clocks trend in the “slower ageing → higher Prysm Score”direction. None individually clears p < 0.05, but the consistency across four clocks plus the tertile gap is strongly suggestive — the kind of signal that would likely reach significance in a larger cohort.
Your Body's Age Scoreboard
High-Prysm Scorers Look Younger Across Every System
How many years younger each body system appears in high-Prysm scorers vs low-Prysm scorers.
Every single system points the same way — high-Prysm scorers look younger across the board.
Based on a collaborative study with Dr Anne Chang (pending publication)
“In a preliminary Stanford study, higher Prysm scores were consistently associated with younger biological age, slower ageing rates and healthier telomere markers across multiple ageing clocks. The consistent trends suggest the relationship warrants further investigation in larger studies.”
Stanford Medicine
Skin & Wellness Factor Correlation Study
This study shows an association between higher Prysm scores and better biological ageing markers.
The Research Behind Your Score
Peer-reviewed science underpins every aspect of how your Prysm Score is calculated.
Carotenoid Biomarkers
Carotenoids are fat-soluble antioxidants found in fruits and vegetables. Research spanning two decades has established skin carotenoid levels as a reliable, non-invasive biomarker for overall nutritional status and antioxidant defence.
Mayne et al. (2010). American Journal of Clinical Nutrition.
Foundational Resonance Raman Research
Resonance Raman spectroscopy research helped establish and validate skin carotenoid concentration as a non-invasive biomarker, with strong correlation to blood serum carotenoid measurements across diverse populations. This foundational science underpins the reference knowledge behind Prysm iO's current Spectral Rai™ measurement technology.
Ermakov et al. (2005). Journal of Biomedical Optics.
Oxidative Stress & Disease
Oxidative stress — caused by an imbalance between free radicals and antioxidants — is implicated in cardiovascular disease, cancer, diabetes, and accelerated ageing. Higher carotenoid levels indicate greater antioxidant capacity.
Lobo et al. (2010). Pharmacognosy Review.
Supplement Efficacy
Clinical trials have shown that carotenoid-rich supplements — when properly formulated and absorbed — significantly raise Prysm Scores within weeks. The score provides objective evidence of supplement effectiveness.
Pharmanex® LifePak® Clinical Studies (2003–2023).
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